From: intc_ctor@... (Phil Tomson)
Date: 2004-01-23T08:09:59+09:00
Subject: Re: Boost Protein Expression by Codon Optimization

jrb3@eidogen.com wrote in message news:<41962.216.135.205.211.1074791313.squirrel@castle>...
> Inadvertant(?) spammer saith:
> 
> >> As we know, codon preference among different species could be
> >> dramatically different.  To enhance the expression level of a foreign
> >> protein in a particular expression system (E.coli, Yeast, Insect, or
> >> Mammalian cell), it is very important to adjust the codon frequency of
> >> the foreign protein to match that of the host expression system.  One
> >> classic example is GFP (green fluorescent protein) which was optimized
> >> to achieve high-level of expression in mammalian cells.
> 
> Joe Mason replies:
> 
> > This is the most surprising spam I've ever seen.
> >
> > Everything is spelled right.
> 
> You think you're surprised?  I work for a company whose customers would be
> customers for this service -- and folks know it.  I can understand my
> mailbox getting this spam, but via ruby-talk???
> 
> Some marketing researcher must have confused "code optimization" for
> "codon optimization" .... ;-) :-)
> 
>         Joseph Beckenbach
>         lead XP tester, Eidogen Inc.


It's quite bizarre, though.  This isn't the sort of business that
sends spam far and wide - they would target their spam ;-).  I wonder
if it ended up in someone's inbox and then they accidentally posted.

But who knows, maybe they did all of this with the DNA implementation
of Ruby ;-)

Phil